Ph.D., D.Sc.,
Full member of the Hungarian Academy of Sciences,
Former Head of the Research Group of Peptide Chemistry
Mail address:
Department of Organic Chemistry, Eötvös L. University,
Budapest 112, Pf. 32. 1518
E-mail: ferenc.hudecz at ttk.elte.hu
Tel: +36-1-372-2828
Fax: +36-1-372-2620
Research Interests:
Peptide- and protein chemistry. Biomolecular chemistry. Immunochemistry
1. Analysis of antigenic structure of proteins. Identificaton of epitopes by classic and combinatorial chemistry. Design of synthetic “superantigens” using peptide and non-peptide epitopes for vaccine and diagnostics development. Prediction, synthesis, conformation and conjugation of viral (herpes simplex virus), bacterial (M.tuberculosis) and tumor associated (mucin) antigenic determinants to synthetic macromolecular carriers.
2. Targeting of antitumour and antimicrobial drugs (e.g. anthracyclines, methotrexate, boron compounds, GnRH) and reporter molecules (fluorophores, radioligands), enzyme substrates and peptide epitopes by oligopeptide or macromolecular bioconjugates. Analysis of mechanism of actions by proteomics.
3. Development of bioconjugation chemistry for covalent coupling of small molecules (epitopes, drugs, reporter molecules) to proteins or peptides.
Publications:
My publications according to the Collection of the Hungarian Scientific Work (MTMT): link
Qualifications:
1972-1977: Diploma in Chemistry (MSc) Eötvös Loránd University (ELTE)
1980: PhD (summa cum laude), ELTE
1986: CSc, Hungarian Academy of Sciences
1993: DSc, Hungarian Academy of Sciences
1996: habilitation, ELTE
1999-2003: private professor, ELTE
2003: full professor, ELTE
2010-2016: corresponding member of the Hungarian Academy of Sciences
2016: full member of the Hungarian Academy of Sciences
Affiliations:
1977-1980: Research assistant (Department of Organic Chemistry, ELTE)
1980-1983: Research assistant (Research Group of Peptide Chemsitry, (RGPC) at Eötvös Loránd University, Hungarian Academy of Sciences)
1984-1985: Assistant Professor (Department of Organic Chemistry, ELTE)
1983-1984: Research Associate (The Wistar Institute, University of Pennsylvania, Philadelphia, Pa. USA)
1985-1988: Research Associate (Department of Organic Chemistry, ELTE)
1988-1989: Associate Professor (Department of Organic Chemistry, ELTE)
1989-1993: Research Associate Professor (Research Group of Peptide Chemistry, (RGPC) at Eötvös Loránd University, Hungarian Academy of Sciences)
1993-2003: Research Professor (Research Group of Peptide Chemistry, (RGPC) at Eötvös Loránd University, Hungarian Academy of Sciences)
1999-2017: Head (Research Group of Peptide Chemistry, (RGPC) at Eötvös Loránd University, Hungarian Academy of Sciences)
2003-: Full Professor (Department of Organic Chemistry, ELTE)
2003-2006: Vice-Rector responsible for Education and Research (ELTE)
2006-2007: Chairman (Department of Organic Chemistry, ELTE)
2006-2010: Rector (ELTE)
2010-2016: Chairman (Department of Organic Chemistry, ELTE)
2016-: Chairman, Board of Professors (Institute of Chemistry, Faculty of Science, Eötvös L. University
Awards:
1986: Junior Research Award (Hungarian Academy of Science)
1995: Pro Scientia medal for supervision (Ministry of Education)
1996: Senior Research Award (Hungarian Academy of Science)
1997: Széchenyi professorship (Ministry of Culture)
1998: Paracelsus Award (Hungarian Society of Chemotherapy)
1999: Science Award, Faculty of Sciences, (ELTE)
2005: Zemplén Géza Award, Hungarian Academy of Sciences
2006: Honoris causa professzor (Sichuan University, China)
2008: Bruckner Győző Award (Hungarian Academy of Sciences/Richter G. Ltd)
2008: Pro European Peptide Society Award (European Peptide Society)
2009: Confucius Institute Individual Performance Excellence Award
(CI Headquarter, Beijing, China)
2010: Socius Honoris Causa ("Foundation for Russian Language and Culture")
2011: Award of the Eötvös Loránd University
2016: Pro European Peptide Society Award (European Peptide Society)
2016: Eötvös Collegium Award (ELTE Eötvös József Collegium)
Reviewer for International Journal:
Anti-Cancer Drugs, Biochem. Biophys. Acta, Bioconjugate Chemistry, Biophysical Chemistry, Biopolymers, FEBS Letters, Immunology Letters, J. Bioactive and Compatible Polymers, J. Drug Targeting, J. Mol. Recognition, J. Peptide Research, J. Peptide Science, Langmuir, Letters in Peptide Science, Tetrahedron.
Editorial Board/Advisory Board Member:
Biokémia (Magyar Biokémiai Egyesület) (1994-2009), Biomedical Peptides, Proteins and Nucleic Acids (UK) (1994-1997), Journal of Bioactive and Compatible Polymers (USA) (1995-2000), Bioconjugate Chemistry (USA) (1998-2006), Journal of Peptide Science (UK) (2001-), Magyar Immunológia (2002-), Current Drug Delivery (2002-)
Associate Editor:
Bioconjugate Chemistry (American Chemical Society, USA) (2007-2014)
Editor:
Specialist Periodical Report, Amino Acids, Peptides and Proteins. The Royal Society of Chemistry, UK (2014-)
Fellowships, professorships (selected):
1983-1984: The Wistar Institute, University of Pennsylvania, Philadelphia (USA), Research Associate, Dr. S.A.Plotkin és Dr. E.Heber-Katz, 15 months,
1988-1989: Cancer Research Campaign (CRC) Laboratories, University of Nottingham, Nottingham (England), Visiting Research Fellowship, Dr. R.W. Baldwin, 10 months,
1991-1992: Department of Microbiology, Kumamoto University (Japan), Visiting Professorship, Dr. H. Maeda, 2 months,
1997: MRC Clinical Sciences Center, London (England), British Royal Society, 1 month, Faculty of Chemistry, Konstanz University, Konztanz (Germany), Professor M. Przybylski, 1 month , guest professor
1999-2000: Institute for Protein Research, Osaka University, Osaka (Japan), Professor Y. Shimonishi, 4 months, guest professor
2004: Faculty of Chemistry, Konstanz University, Konztanz (Germany), 1 month, guest professor
2012: Nagahama Institute of Bio-Science and Technology, Nagahama, Japan, 1 week
2014: Keimyung University, Daegu, Korea, 1 week
Invited Lectures at International Meetings (selected):
1991: 5th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, USA
1993: 3rd International Symposium on Solid Phase Synthesis, Oxford, Anglia
1995: Biodegradable Polymers. Gordon Research Conference, Oxnard, USA
1995: 4th International Symposium on Innovation and Perspective in Solid Phase Synthesis and Related Technologies, Edinburgh, UK.
1995: Trends in Microbiology, Calcutta, India
1997: Biodegradable Polymers. Gordon Research Conference, Pisa, Italy
1997: 2nd International Symposium on Polymer Therapeutics, Kumamoto, Japan
1997: 8th European Congress on Biotechnology, Budapest, Hungary
1997: Biodegradable Polymers. Gordon Research Conference, Pisa, Italy
1997: 5th International Symposium on Solid Phase Synthesis, London, UK
1998: Advances in Peptide, Protein and Nucleic Acid Vaccine Strategies. International Symposium. Oxford, UK [co-chairman]
1999: Self-assembly polymers, Crete, Greece
1999: 6th International Symposium on Innovation and Perspective in Solid Phase Synthesis and Related Technologies, York, UK
2000: Protein 2000, London, Anglia, UK [vice-president]
2001: Biodegradable Polymers. Gordon Research Conference, Oxford, UK
2001: 7th International Symposium on Innovation and Perspective in Solid Phase Synthesis and Related Technologies, Southampton, UK [co-chairman]
2002: 3rd Hellenic Forum on Bioactive Peptides, Patras, Greece
2003: 8th International Symposium on Innovation and Perspective in Solid Phase Synthesis and Related Technologies, London, UK [co-chairman]
2004: 4th Hellenic Forum of Bioactive Peptides, Patras, Greece
2004: 9th Naples Workshop of Bioactive Peptides, Anacapri, Italy,
2004: 1st Asia-Pacific International Peptide Symposium, Fukuoka, Japan
2005: "Mechanisms of Carrier-Mediated Intracellular Delivery of Therapeutics", Satellite meeting, 15th IUPAB, Montpellier, France
2005: 1st European Conference on Chemistry for Life Sciences, Rimini, Italy,
2006: 5th Hellenic Forum of Bioactive Peptides, Patras, Greece
2006: 43rd Japanese Peptide Symposium, Yokohama, Japan
2007: 2nd European Conference on Chemistry for Life Sciences, Wroclaw, Poland
2007: 9th International Symposium on Innovation and Perspective in Solid Phase Synthesis and Related Technologies, Norwich, UK, [co-chairman]
2008: 6th Hellenic Forum of Bioactive Peptides, Patras, Greece
2010: 5th International Peptide Symposium, Kyoto, Japan
2011: 17th International Conference on Chemistry, Cluj-Napoca/Kolozsvár, Románia
2011: Bioaffinity-Mass Spectrometry: New Developments and Applications in Life Sciences, Konstanz, Germany
2012: 2nd International Conference on "Perspectives of Cell Signaling and Molecular Medicine", Calcutta, India
2012: 12th Chinese International Peptide Symposium, Shenyang, China
2012: 2nd Irish Peptide Workshop, University of Ulster, Coleraine, Irország
2013: 23rd American Peptide Symposium/6th International Peptide Symposium, Hawaii, USA
2013: 4th Asia-Pacific International Peptide Symposium, in conjunction with 50th Japanese Peptide Symposium, Osaka, Japan
2015: 23rd Polish Peptide Symposium, Spala, Poland
2015: 11st Australian Peptide Conference, Kingscliff, Australia
2016: 5th Asia-Pacific International Peptide Symposium, in conjunction with 14th Chinese Peptide Symposium, Nanking, China
2016: 15th Naples Workshop on Bioactive Peptides, Naples, Italy
2017: 3rd International Conference on "Perspectives of Cell Signaling and Molecular Medicine" Calcutta, India
Member of the Scientifc/Advisory Committee (selected):
1997: 2nd International Symposium on Polymer Therapeutics, Kumamoto, Japan
2000: 4th International Symposium on Polymer Therapeutics, London, UK
2000: Protein 2000, London, Anglia, UK
2000: 16th International Conference on Chemical Education, Budapest, Hungary
2000: 26th European Peptide Symposium - 2000, Montpellier, France
2001: 7th International Symposium on Innovation and Perspective in Solid Phase Synthesis and Related Technologies, Southampton, UK
2001: 5th International Symposium on Polymer Therapeutics -2002, Cardiff, UK
2002: 27th European Peptide Symposium - 2002, Sorrento, Italy
2003: 8th International Symposium on Innovation and Perspective in Solid Phase Synthesis and Related Technologies, London, UK
2004: 4th International Symposium on Polymer Therapeutics, Kumamoto, Japan
2005: 30th FEBS Meeting and IUBM Congress, Budapest, Hungary
2006: 29th European Peptide Symposium - 2006, Gdansk, Poland
2006: 1st European Chemistry Conference, Budapest, Hungary
2006: 5th Hellenic Forum of Bioactive Peptides, Patras, Greece
2007: 1st International Symposium on Combinatorial Sciences, Firenze, Italy
2007: 9th International Symposium on Innovation and Perspective in Solid Phase Synthesis and Related Technologies, Norwich, UK
2008: 30th European Peptide Symposium - 2008, Helsinki, Finland
2009: 3rd Asia-Pacific International Peptide Symposium, Jeju Island, Republic of Korea
2010: 5th International Peptide Symposium, Kyoto, Japan
2012: 32nd European Peptide Symposium, Athens, Greece
2012: 2nd International Conference on "Perspectives of Cell Signaling and Molecular Medicine" Calcutta, India
2014: 33rd European Peptide Symposium, Sophia, Bulgaria
2014: 14th Naples Workshop on Bioactive Peptides, Naples, Italy
2015: 7th International Peptide Symposium, Singapore
2016: 15th Naples Workshop on Bioactive Peptides, Naples, Italy
2016: 5th Asia-Pacific International Peptide Symposium, in conjunction with 14th Chinese Peptide Symposium, Nanking, China
2017: 3rd International Conference on "Perspectives of Cell Signaling and Molecular Medicine" Calcutta, India
2018: 10th International Peptide Symposium, in conjunction with 55th Japanese Peptide Symposium, Kyoto, Japan
International Conferences organised (selected):
1990: Workshop on Bioconjugates, 20th FEBS Meeting, Budapest, Hungary
1992: “Prediction and Recognition of Antigenic Determinants”, a satellite conference of the 8th International Immunology Congress, Budapest, Hungary
1998: 25th European Peptide Symposium, Budapest, Hungary
2003: Cellular Transport Strategies for Targeting, EU5 QoL Workshop, Budapest, Hungary
2005: Peptide and Protein Bioconjugates, 30th FEBS Meeting and IUBM Congress, Budapest, Hungary
2011: 4th European Conference on Chemistry for Life Sciences, Budapest, Hungary
2014: 20th International Conference on Organic Synthesis (ICOS-20), Budapest, Hungary
2014: Chemical Approaches to Targeting Drug Resistance in Cancer Stem Cells, EU COST "Chemistry and Molecular Sciences and Technologies Action CM1106", Budapest, Hungary
Extramural Appointments:
1991-1994: Chairman of the Programme Committee, TEMPUS Joint European Project (JEP 2113) on “Modern Approaches in Biomedical Sciences”
1991-: Member of the National Committee of the PUGWASH Conferences
1993-: Secretary of the Peptide Committee, Hungarian Academy of Science
1997-: Member of the Board of Trustees, Secretary, Foundation for Hungarian protein and peptide research
1997-: Chairman, DSc Council of Chemistry, Hungarian Academy of Science
1998: 25th European Peptide Symposium, Budapest, Secretary of the Organising Committee
1999-2006: Member of the Council of the Division of Chemistry, Faculty of Natural Sciences, Eötvös L. University
2000-: Member and Secretary of the Division of Organic- and Biomolecular Committee, Hungarian Academy of Science
2000-2008: Secretary of the European Peptide Society
2000: COST Chemistry D13 Working Group, Co-ordinator
2000: President of the Board of Trustees, Secretary, Foundation for Hungarian protein and peptide research
2001-2006: Member of Hungarian Accreditation Agency, Division of Chemistry
2006-2010: President of the University Senate
2007-2012: Member of the National Funding Agency
2010-: Member of the Hungarian Academy of Sciences
2010-2016: President of the European Peptide Society
2010-2013: Founding Member, Academic Executive Advisory Board (AEAB), Elsevier B.V., Amsterdam, The Netherlands
2010-: Senior Consultant to the Confucius Institute Headquarter, Beijing, China
2011-: Member, Council of DSc, HAS, co-chair (since 2014)
2011-: Honorary Member, Council of the Confucius Institute Headquarters, Beijing, China
2014-: Honorary President of Danube Rectors Conference (DRC)
2014-: Member, Supervisory board HAS
2015-: Chairman, Kisfaludy Lajos Foundation
2017: President, Supervisory board HAS
Training, education experience:
Organic Chemistry, major
Structure-function relationship of drugs I.
Structure-function relationship of drugs II.
Supervision of final year BSc/MSc students (36)
Supervision of PhD students (16)
Bioconjugates (PhD lecture course)
Selected chapters from peptide- and protein chemistry (PhD lecture course)
