Scientific Profile: Fields of Research                      Váltás magyarra

 

 

 

Research at the Research Group of Peptide Chemistry (RGPC) has been closely related to priorities of EU, NATO and WHO, international collaborations supported by Hungarian (OTKA, OMFB, Ministry of Education, Ministry of Health, Hungarian Academy of Sciences), and international agencies (WHO, EACR, NATO, EU-COST). RGPC is involved in contract research for Hungarian (Reanal, Biosignal, G. Richter) and foreign companies (Pliva, Croatia; Veterinary Agency, UK; Unilever, UK). RGPC has 8 researchers. All of them possess at least PhD. Average age is 41 year. During the last three years 60 research papers were published in international journals and 27 contributions were made to ISBN books. 105 lectures/posters were presented mainly (72) at international conferences. Staff members are also acting as supervisors in 3 PhD programs of Eötvös L. University. 6 PhD thesis, 14 diploma thesis were produced during the last three years. 

 

 

Fields of interest:

 

Chemical synthesis and structural characterisation of peptides, peptide chimera, and bioconjugates for (i) the discovery of structure-activity relationship, (ii) development of peptide-antigens as vaccines/diagnostics or drugs and (iii) targeting/delivery of peptide epitopes/drugs.

 

 

Main topics:

 

1. Identification and structural manipulation of B- and T-cell epitopes derived from proteins of microbial (M. tuberculosis, HSV, HIV), tumor and of autoimmune origin for vaccine and diagnostics development.

 

2. Targeting/delivery of peptide epitopes/drugs/reporter molecules. Identification of protein sequences suitable for intracellular targeting. Design, preparation and stability studies of oligopeptide- and polymeric/sequential polypeptide-cargo conjugates for improved diagnosis and therapy. Studies on the mechanism of action by proteomics.

 

3. Identification, synthesis and characterization of oligopeptides and their analogs, labelled derivates related to neurological disorders, structure-function studies.

 

4. Analysis of decomposition of modified peptides and peptide-conjugates in complex biological mixtures (e.g. human serum, lysosome preparation) and detection of peptide/protein complexes by mass spectrometry.

 

 

 

 

 

International Conferences organised

 

 

1990

Workshop on Bioconjugates, 20th FEBS Meeting, Budapest,

1992

Prediction and Recognition of Antigenic Determinants, a Satellite Meeting of the 8th International Congress of Immunology, Budapest,

1995

Synthetic Polymers in Drug Delivery Research, 3rd Annual Meeting of the SPIDER Network (EU PECO Initiative), Budapest,

1998

25th European Peptide Symposium, Budapest, 1998,

2000

Peptide Based Synthetic Antigens Against Infectious Diseases, 1st Annual Meeting of the Working Group (COST), Budapest,

2003

Workshop on "Cellular Transport Strategies for Targeting  Epitopes, Drugs and Reporter Molecules" (QLAM-CT-2002-30585), EU FP5 Quality of Life

2005

Workshop on Bioconjugates, 30th FEBS Meeting, Budapest

 

 

 

Váltás magyarra (change to Hungarian)