Nyelv(ek):angol

Tartalom:
-Peptidek szintézise
-szerves kémia, peptidek, szintézis, védőcsoportok, racemizáció, szilárd fázisú peptidszintézis (SPPS)
-kémia
-(35 fejezet)

Fejezetek:
*Part-1:Introduction, etc. (3 chapters) (1-13 p.)
*Introduction: References, Proceedings of the European Peptide Symposia, Proceedings of the American Peptide Symposia, Monographs on peptide synthesis, Selected review articles on peptide synthesis (1-5 p.)
*Historical aspects and perspectives: Toward biologically active peptides, Synthetic methods, New techniques, References (5-10 p.)
*Problems of peptide synthesis: Coupling, Protecting groups, Racemization, Strategy and techniques, References (10-13 p.)
*Part-2:Easily removable protecting groups and their removal (10 chapters) (13-85 p.)
*Protection of amino groups: Amine hydrochlorides, The p-toluenesulfonyl group, The benzyloxycarbonyl (carbobenzoxy) group, Substituted benzyloxycarbonyl and other urethane-type protecting groups, The t-butyloxycarbonyl group, Thiourethane-type derivatives, The trifluoroacetyl group, The chloroacetyl group, The phthalyl group, The formyl group, The acetoacetyl group, The 4,5-diphenyl-4-oxazolin-2-one (ox) group, the benzyl/diphenylinethyl (benzhydryl) and triphenylmethyl (trityl) groups, Lactams, Schiff bases and enamines, Tritylsulfenyl and arylsulfenyl groups) (13-49 p.)
*Protection of carboxyl groups: Salt formation, Methyl and ethyl esters, Benzyl and benzhydryl esters, Substituted benzyl esters, Phthalimidomethyl esters, Tertiary butyl esters, Phenacyl esters, Phenyl esters, 4-Picolyl esters, 2-Methylthioethyl/2(p-toluenesulfonyl)ethyl and 2(p-nitrothiophenyl)ethyl esters, p-Methylthiophenyl esters, Hydrazides, Selective protection of carboxyl groups of monoaminodicarboxylicacids (49-58 p.)
*Protection of hydroxyl groups: O-Acyl derivatives, O-Alkyl derivatives (58-60 p.)
*Protection of sulfhydryl groups (60-61 p.)
*Protection of the imidazole nitrogen of histidine: N-im-Benzylhistidine, N-im-Tritylhistidine, N-im-Benzyloxycarbonylhistidine, N-im-t-Butyloxycarbonylhistidine, N-im-Adamantyloxycarbonylhistidine, N-im-Piperidinocarbonylhistidine, N-im-2,4-Dinitrophenylhistidine (61-67 p.)
*Protection of the guanidino group of arginine (67-68 p.)
*Protection of amide side chains (68-69 p.)
*Protection of the thio ether group in methionine: (69 p.)
*Protection of the indole ring in tryptophan (69 p.)
*References (69-85 p.)
*Part-3:Formation of the peptide bond (6 chapters) (85-137 p.)
*Reactive derivatives of the carboxyl component: The azide method, The acid chloride method, The acid anhydride methods, Activated and active esters (85-109 p.)
*Reactive derivatives of the amino component (109-111 p.)
*Reactive N-acyl derivatives (111-114 p.)
*Coupling reagents: Carbodiimides, Isoxazolium derivatives, EEDQ, Phosphonium derivatives (114-125 p.)
*Nonconventional methods of coupling (125-128 p.)
*References (128-137 p.)
*Part-4:Racemization (7 chapters) (137-158 p.)
*Mechanisms of racemization (137-143 p.)
*Racemization during introduction and removal of protecting groups (143-144 p.)
*Racemization during peptide bond formation: Influence of the amino protecting group, Influence of the coupling methods, Influence of the individual amino acids (144-149 p.)
*Methods for the study of racemization (149-150 p.)
*Examination of the optical purity of synthetic peptides (150-151 p.)
*Prevention of racemization (151-153 p.)
*References.(153-158 p.)
*Part-5:Solid phase peptide synthesis and other techniques for the facilitation of synthetic procedures (4 chapters) (158-177 p.)
*Solid phase peptide synthesis (SPPS): The polymeric support, The bond between peptide chain and polymer, Alpha-amino protecting groups and their removal in SPPS, Side chain protection in SPPS, Formation of the peptide bond in SPPS, Racemizaiton in SPPS, Cleavage of the completed peptide chain from the polymeric support, Mechanization/automation and monitoring in SPPS (158-169 p.)
*Polymer-bound reagents (169-170 p.)
*Facilitation of synthesis in solution: Isolation of intermediates with the aid of polymers, Synthesis of peptide chains without isolation of intermediates, "In situ" peptide synthesis (172-173 p.)
*References (173-177 p.)
*Part-6:Strategy and tactics of peptide synthesis (5 chapters) (177-197 p.)
*Strategy: Stepwise elongation from the N-terminal amino acid, Stepwise elongation from the C-terminal amino acid, Fragment condensation (177-182 p.)
*Tactics in the selection of protecting groups and coupling methods (182-187 p.)
*Special problems: Disulfide bonds, Cyclic peptides (187-192 p.)
*Purification of intermediates and final products in peptide synthesis (192 p.)
*References (192-197 p.)