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Professor Ferenc Hudecz Ph.D., D.Sc., Corresponding member of the Hungarian Academy of Sciences, Head of the Research Group of Peptide Chemistry Mail address: Department of Organic Chemistry, Eötvös L. University, Budapest 112, P.O.Box 32, H-1518, Hungary Email: fhudecz@@@ludens.elte.hu Tel: +36-1-372-2828 Fax: +36-1-372-2620 váltás magyarra

Short CV: Qualifications: 1972-1977 Diploma in Chemistry (MSc) Eötvös Loránd University (ELTE) 1980 PhD (summa cum laude), ELTE 1986 CSc, Hungarian Academy of Sciences (HAS) 1993 DSc, Hungarian Academy of Sciences (HAS) 1996 habilitation, ELTE 1999 private professor, ELTE 2003 full professor, ELTE 2010 corresponding member of the Hungarian Academy of Sciences Affiliations: 1977-1980 Research assistant (Department of Organic Chemistry, ELTE) 1980-1983 Research assistant (Research Group of Peptide Chemsitry, (RGPC) at Eötvös Loránd University, Hungarian Academy of Sciences) 1984-1985 Assistant Professor (Department of Organic Chemistry, ELTE) 1983-1984 Research Associate (The Wistar Institute, University of Pennsylvania, Philadelphia, Pa. USA) 1985-1988 Research Associate (Department of Organic Chemistry, ELTE) 1988-1989 Associate Professor (Department of Organic Chemistry, ELTE) 1989-1993 Research Associate Professor (Research Group of Peptide Chemistry, (RGPC) at Eötvös Loránd University, Hungarian Academy of Sciences) 1993-2003 Research Professor (Research Group of Peptide Chemistry, (RGPC) at Eötvös Loránd University, Hungarian Academy of Sciences) 1999- Head (Research Group of Peptide Chemistry, (RGPC) at Eötvös Loránd University, Hungarian Academy of Sciences) 2003- Full Professor (Department of Organic Chemistry, ELTE) 2003-2006 Vice-Rector responsible for Education and Research (ELTE) 2006-2010 Rector (ELTE) 2010- Head (Department of Organic Chemistry, ELTE) Awards: 1986 Junior Research Award (Hungarian Academy of Science) 1995 Pro Scientia medal for supervision (Ministry of Education) 1996 Senior Research Award (Hungarian Academy of Science) 1997 Széchenyi professorship (Ministry of Culture) 1998 Paracelsus Award (Hungarian Society of Chemotherapy) 1999 Science Award, Faculty of Sciences, (ELTE) 2005 Zemplén Géza Award, Hungarian Academy of Sciences 2006 Honoris causa professzor (Sichuan University, China) 2008 Bruckner Győző Award (Hungarian Academy of Sciences/Richter G. Ltd) 2008 Pro European Peptide Society Award (European Peptide Society) Reviewer for International Journal: Anti-Cancer Drugs, Biochem. Biophys. Acta, Bioconjugate Chemistry, Biophysical Chemistry, Biopolymers, FEBS Letters, Immunology Letters, J. Bioactive and Compatible Polymers, J. Drug Targeting, J. Mol. Recognition, J. Peptide Research, J. Peptide Science, Langmuir, Letters in Peptide Science, Tetrahedron. Editorial Board/Advisory Board Member: Biokémia (Magyar Biokémiai Egyesület) (1994-), Biomedical Peptides, Proteins and Nucleic Acids (UK) (1994-1997), Journal of Bioactive and Compatible Polymers (USA) (1995-), Bioconjugate Chemistry (USA) (1998-), Journal of Peptide Science (UK) (2001-), Magyar Immunológia (2002-), Current Drug Delivery (2002-), Associate Editor: Bioconjugate Chemistry (American Chemical Society, USA) (2007- ) Fellowships, professorships (selected): 1983-84 The Wistar Institute, University of Pennsylvania, Philadelphia (USA), Research Associate, Dr. S.A.Plotkin és Dr. E.Heber-Katz, 15 months, 1988-89 Cancer Research Campaign (CRC) Laboratories, University of Nottingham, Nottingham (England), Visiting Research Fellowship, Dr. R.W. Baldwin, 10 months, 1991-92 Department of Microbiology, Kumamoto University (Japan), Visiting Professorship, Dr. H. Maeda, 2 months,, 1997 MRC Clinical Sciences Center, London (England), British Royal Society, 1 month, Faculty of Chemistry, Konstanz University, Konztanz (Germany), Professor M. Przybylski, 1 month , guest professor 1999-2000 Institute for Protein Research, Osaka University, Osaka (Japan), Professor Y. Shimonishi, 4 months, guest professor 2004 Faculty of Chemistry, Konstanz University, Konztanz (Germany), 1 month, guest professor Invited Lectures at International Meetings (selected): 1991 5th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, USA 1993 3rd International Symposium on Solid Phase Synthesis, Oxford, Anglia 1995 Biodegradable Polymers. Gordon Research Conference, Oxnard, USA 1995 4th International Symposium on Innovation and Perspective in Solid Phase Synthesis and Related Technologies, Edinburgh, UK. 1995 Trends in Microbiology, Calcutta, India 1997 Biodegradable Polymers. Gordon Research Conference, Pisa, Italy 1997 2nd International Symposium on Polymer Therapeutics, Kumamoto, Japan 1997 8th European Congress on Biotechnology, Budapest, Hungary 1997 Biodegradable Polymers. Gordon Research Conference, Pisa, Italy 1997 5th International Symposium on Solid Phase Synthesis, London, UK 1998 Advances in Peptide, Protein and Nucleic Acid Vaccine Strategies. International Symposium. Oxford, UK [co-chairman] 1999 Self-assembly polymers, Crete, Greece 1999 6th International Symposium on Innovation and Perspective in Solid Phase Synthesis and Related Technologies, York, UK 2000 Protein 2000, London, Anglia, UK [vice-president] 2001 Biodegradable Polymers. Gordon Research Conference, Oxford, UK 2001 7th International Symposium on Innovation and Perspective in Solid Phase Synthesis and Related Technologies, Southampton, UK [co-chairman] 2002 3^rd Hellenic Forum on Bioactive Peptides, Patras, Greece 2003 8th International Symposium on Innovation and Perspective in Solid Phase Synthesis and Related Technologies, London, UK [co-chairman] 2004 4^th Hellenic Forum of Bioactive Peptides, Patras, Greece 2004 9^th Naples Workshop of Bioactive Peptides, Anacapri, Italy, 2004 1^st Asia-Pacific International Peptide Symposium, Fukuoka, Japan 2005 "Mechanisms of Carrier-Mediated Intracellular Delivery of Therapeutics", Satellite meeting, 15^th IUPAB, Montpellier, France 2005 1^st European Conference on Chemistry for Life Sciences, Rimini, Italy, 2006 5^th Hellenic Forum of Bioactive Peptides, Patras, Greece 2006 43^rd Japanese Peptide Symposium, Yokohama, Japan 2007 2^ndEuropean Conference on Chemistry for Life Sciences, Wroclaw, Poland 2007 9th International Symposium on Innovation and Perspective in Solid Phase Synthesis and Related Technologies, Norwich, UK, [co-chairman] 2008 6^th Hellenic Forum of Bioactive Peptides, Patras, Greece 2010 5^th International Peptide Symposium, Kyoto, Japan Member of the Program Committee 1997 2nd International Symposium on Polymer Therapeutics, Kumamoto, Japan 2000 4th International Symposium on Polymer Therapeutics, London, UK 2000 Protein 2000, London, UK 2000 16th International Conference on Chemical Education, Budapest, Hungary 2000 26th European Peptide Symposium - 2000, Montpellier, France 2001 7th International Symposium on Innovation and Perspective in Solid Phase Synthesis and Related Technologies, Southampton, UK 2001 5th International Symposium on Polymer Therapeutics -2002, Cardiff, UK 2002 27^th European Peptide Symposium - 2002, Sorrento, Italy 2003 8th International Symposium on Innovation and Perspective in Solid Phase Synthesis and Related Technologies, London, UK 2003 Polish, German, Hungarian, Italian Joint meeting on Medicinal Chemistry, Krakow, Poland 2004 4^th International Symposium on Polymer Therapeutics, Kumamoto, Japan 2005 30^th FEBS Meeting and IUBM Congress, Budapest, Hungary 2006 29^th European Peptide Symposium - 2006, Gdansk, Poland 2006 1^st European Chemistry Conference, Budapest, Hungary 2006 5^th Hellenic Forum of Bioactive Peptides, Patras, Greece 2007 1^st International Symposium on Combinatorial Sciences, Firenze, Italy 2007 9th International Symposium on Innovation and Perspective in Solid Phase Synthesis and Related Technologies, Norwich, UK 2008 30^th European Peptide Symposium - 2008, Helsinki, Finland 2009 3^rd Asia-Pacific International Peptide Symposium, Jeju Island, Republic of Korea 2010 5^th International Peptide Symposium, Kyoto, Japan International Conferences organised (selected): 1990 Workshop on Bioconjugates, 20th FEBS Meeting, Budapest 1992 “Prediction and Recognition of Antigenic Determinants”, a satellite conference of the 8th International Immunology Congress, Budapest 1998 25th European Peptide Symposium, Budapest 2003 Cellular Transport Strategies for Targeting…, EU5 QoL Workshop, Budapest 2005 Peptide and Protein Bioconjugates .., 30^th FEBS Meeting and IUBM Congress, Budapest 2011 4^th European Conference on Chemistry for Life Sciences, Budapest, Hungary Extramural Appointments: 1991-94 Chairman of the Programme Committee, TEMPUS Joint European Project (JEP 2113) on “Modern Approaches in Biomedical Sciences” 1991- Member of the National Committee of the PUGWASH Conferences 1993- Secretary of the Peptide Committee, Hungarian Academy of Science 1997- Member of the Board of Trustees, Secretary, Foundation for Hungarian protein and peptide research 1997- Chairman, DSc Council of Chemistry, Hungarian Academy of Science 1998 25th European Peptide Symposium, Budapest, Secretary of the Organising Committee 1999- Member of the Council of the Division of Chemistry, Faculty of Natural Sciences, Eötvös L. University 2000- Member and Secretary of the Division of Organic- and Biomolecular Committee, Hungarian Academy of Science 2000- 08 Secretary of the European Peptide Society 2000 COST Chemistry D13 Working Group, Co-ordinator 2000 President of the Board of Trustees, Secretary, Foundation for Hungarian protein and peptide research 2001-06 Member of Hungarian Accreditation Agency, Division of Chemistry 2006-10 President of the University Senate 2007- Member of the National Funding Agency 2010- Member of the Hungarian Academy of Sciences 2010- President of the European Peptide Society Research Interests: Peptide- and protein chemistry. Biomolecular chemistry. Immunochemistry. 1. Analysis of antigenic structure of proteins. Identificaton of epitopes by classic and combinatorial chemistry. Design of synthetic “superantigens” using peptide and non-peptide epitopes for vaccine and diagnostics development. Prediction, synthesis, conformation and conjugation of viral (herpes simplex virus), bacterial (M.tuberculosis) and tumor associated (mucin) antigenic determinants to synthetic macromolecular carriers. 2. Targeting of antitumour and antimicrobial drugs (e.g. anthracyclines, methotrexate, boron compounds, GnRH) and reporter molecules (fluorophores, radioligands), enzyme substrates and peptide epitopes by oligopeptide or macromolecular bioconjugates. Analysis of mechanism of actions by proteomics. 3. Development of bioconjugation chemistry for covalent coupling of small molecules (epitopes, drugs, reporter molecules) to proteins or peptides. Scientific publications: Articles (in SCI journals) 195 Abstract in SCI journals 109 Book chapter (ISBN) 119 Patents 5 Lecture at International meetings 529 Lecture at National meetings 150 Invited, plenary lectures 26 Training, education experience: Organic Chemistry, major Structure-function relationship of drugs I. Structure-function relationship of drugs II. Supervision of final year master students Supervision of undergraduate students Supervision of PhD students Bioconjugates (PhD lecture course) Selected chapters from peptide- and protein chemistry (PhD lecture course) Lectures in English EU-TEMPUS "Modern Techniques in Biomedical Sciences" (JEP 2113) (1991-1994) "Methods of Analytical Biochemistry and Molecular Biology", International Summer School program, (Faculty of Chemistry, University of Konstanz) 1999. “Protein-based bioconjugates” ERASMUS Professor, Faculty of Chemistry, University of Konstanz, 2001 “Recent advances in peptide synthesis.” ERASMUS Professor, Faculty of Chemistry, University of Konstanz, 2004 “Peptide chemistry – a short course” University of Helsinki, Finland, 2004 “Bioconjugates”, Kitasato University, 2004, Kinki University, Japan, 2005